MolNFT v1 · #105891 · protein
Chimeric glycosyltransferase LANGT2S8AC, tdp complex
4RII · Glycosyl transferase HOMOLOG,GLYCOSYL transferase: “Chimeric glycosyltransferase LANGT2S8AC, tdp complex”. X-ray diffraction, 2 ligands (TYD, MG), 7 pockets (best druggability 0.76). MolNFT v1 #105891 on GenesisL1: 3D structure…
- PDB
- 4RII
- Type
- protein
- Length
- 710 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycosyl transferase HOMOLOG,GLYCOSYL transferase
- UniProt
- Q9ZGC0, Q9RPA7
- Ligands
- TYD, MG
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycosyl transferase HOMOLOG,GLYCOSYL transferase | protein | 354 | 45% helix, 15% strand | Q9ZGC0, Q9RPA7 |
| B | Glycosyl transferase HOMOLOG,GLYCOSYL transferase | protein | 356 | 44% helix, 15% strand | Q9ZGC0, Q9RPA7 |
Ligands and binding sites
- TYD · Thymidine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.76 | 0.84 | 59 | TYD |
| 2 | 505 | 0.73 | 0.81 | 50 | TYD |
| 3 | 131 | 0.58 | 0.84 | 29 | empty |
| 4 | 156 | 0.55 | 0.81 | 28 | empty |
| 5 | 163 | 0.42 | 0.73 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1637 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4RII · Chimeric Glycosyltransferase LanGT2S8Ac, TDP complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZGC0
- Every structure of UniProt Q9RPA7
- Elsewhere: RCSB PDB 4RII · PDBe 4RII · UniProt Q9ZGC0 · UniProt Q9RPA7
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