MolNFT v1 · #105886 · protein

Human FAN1 nuclease

4RID · Fanconi-associated nuclease 1: “Human FAN1 nuclease”. X-ray diffraction, 13 pockets (best druggability 0.71). MolNFT v1 #105886 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RID
Type: protein
Length: 1,243 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi-associated nuclease 1
EC: 3.1.21.-, 3.1.4.1
UniProt: Q9Y2M0
Pockets: 13 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fanconi-associated nuclease 1 (EC 3.1.21.-, 3.1.4.1)	protein	615	55% helix, 6% strand	Q9Y2M0
B	Fanconi-associated nuclease 1 (EC 3.1.21.-, 3.1.4.1)	protein	628	53% helix, 6% strand	Q9Y2M0

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.71	0.79	82	empty
2	158	0.66	0.87	31	empty
3	247	0.64	0.82	43	empty
4	54	0.62	0.94	20	empty
5	151	0.47	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 1473 Å² buried · 54 hydrogen bonds · protein-protein

Compared structures

4RID · Human FAN1 nuclease · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y2M0 · AlphaFold monomer V2.0 prediction for fanconi-associated nuclease 1 (Q9Y2M0) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y2M0
Elsewhere: RCSB PDB 4RID · PDBe 4RID · UniProt Q9Y2M0

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