MolNFT v1 · #105860 · protein

Histidine triad nucleotide-binding protein (hint) from rabbit complexed with adenosine

4RHN: “Histidine triad nucleotide-binding protein (hint) from rabbit complexed with adenosine”. X-ray diffraction, 1 ligand (RIB), 2 pockets (best druggability 0.33). MolNFT v1 #105860 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4RHN
Type: protein
Length: 115 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histidine triad nucleotide-binding protein
UniProt: P80912
Ligands: RIB
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histidine triad nucleotide-binding protein	protein	115	29% helix, 22% strand	P80912

Ligands and binding sites

RIB · alpha-D-ribofuranose · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.33	0.74	17	RIB
2	50	0.24	0.73	14	empty

Compared structures

4RHN · Histidine triad nucleotide-binding protein (hint) from rabbit complexed with adenosine · the same entry in another collection · chain A against A, TM-score 1.00
P80912 · AlphaFold monomer V2.0 prediction for histidine triad nucleotide- binding protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P80912
Elsewhere: RCSB PDB 4RHN · PDBe 4RHN · UniProt P80912

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