MolNFT v1 · #105855 · protein
Crystal structure of semet-labeled wild-type T. brucei arginase-like protein in P321 space group
4RHI: “Crystal structure of semet-labeled wild-type T. brucei arginase-like protein in P321 space group”. X-ray diffraction, 10 pockets (best druggability 0.73). MolNFT v1 #105855 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4RHI
- Type
- protein
- Length
- 623 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginase
- EC
- 3.5.3.1
- UniProt
- Q581Y0
- Pockets
- 10 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Arginase (EC 3.5.3.1) | protein | 316 | 32% helix, 18% strand | Q581Y0 |
| B | Arginase (EC 3.5.3.1) | protein | 307 | 33% helix, 18% strand | Q581Y0 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.73 | 0.80 | 47 | empty |
| 2 | 502 | 0.70 | 0.79 | 41 | empty |
| 3 | 255 | 0.52 | 0.76 | 42 | empty |
| 4 | 213 | 0.52 | 0.77 | 39 | empty |
| 5 | 57 | 0.42 | 0.82 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 427 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 23 modified (engineered).
Compared structures
- 4RHI · Crystal structure of SeMet-labeled wild-type T. brucei arginase-like protein in P321… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q581Y0
- Elsewhere: RCSB PDB 4RHI · PDBe 4RHI · UniProt Q581Y0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.