MolNFT v1 · #105844 · protein

Crystal structure of human cytoplasmic dynein 2 motor domain in complex with ADP.VI

4RH7 · Green fluorescent PROTEIN/CYTOPLASMIC dynein 2 heavy chain 1: “Crystal structure of human cytoplasmic dynein 2 motor domain in complex with ADP.VI”. X-ray diffraction, 4 ligands (ADP, AOV, ATP), 20 pockets (best druggability 0.88).…

PDB: 4RH7
Type: protein
Length: 3,005 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Green fluorescent PROTEIN/CYTOPLASMIC dynein 2 heavy chain 1
UniProt: Q8NCM8
Ligands: ADP, AOV, ATP, MG
Pockets: 20 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Green fluorescent PROTEIN/CYTOPLASMIC dynein 2 heavy chain 1	protein	3005	57% helix, 9% strand	Q8NCM8

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A
AOV · Adp orthovanadate · ligand · chains A
ATP · Adenosine-5'-triphosphate · ligand · chains A
MG · Magnesium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	738	0.88	0.91	104	ADP
2	599	0.84	0.89	77	AOV
3	1044	0.83	0.84	90	ADP
4	142	0.81	0.96	32	empty
5	679	0.78	0.83	65	empty

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NCM8
Elsewhere: RCSB PDB 4RH7 · PDBe 4RH7 · UniProt Q8NCM8

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