MolNFT v1 · #105820 · protein

Apo crystal structure of CDPK4 from plasmodium falciparum, PF3D7_0717500

4RGJ · Calcium-dependent protein kinase 4: “Apo crystal structure of CDPK4 from plasmodium falciparum, PF3D7_0717500”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #105820 on GenesisL1: 3D structure, binding sites and…

PDB: 4RGJ
Type: protein
Length: 463 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-dependent protein kinase 4
EC: 2.7.11.1
UniProt: Q8IBS5
Pockets: 5 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calcium-dependent protein kinase 4 (EC 2.7.11.1)	protein	463	53% helix, 14% strand	Q8IBS5

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1001	0.77	0.79	89	empty
2	92	0.76	0.97	29	empty
3	92	0.46	0.81	16	empty
4	65	0.37	0.78	18	empty
5	50	0.26	0.74	14	empty

Compared structures

4RGJ · Apo crystal structure of CDPK4 from Plasmodium falciparum, PF3D7_0717500 · the same entry in another collection · chain A against A, TM-score 1.00
Q8IBS5 · AlphaFold monomer V2.0 prediction for calcium-dependent protein kinase 4 (Q8IBS5) · a predicted model of the same protein · chain A against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IBS5
Elsewhere: RCSB PDB 4RGJ · PDBe 4RGJ · UniProt Q8IBS5

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