MolNFT v1 · #105628 · protein

Crystal structure of RV1600 encoded aminotransferase from mycobacterium tuberculosis

4RAE · Histidinol-phosphate aminotransferase: “Crystal structure of RV1600 encoded aminotransferase from mycobacterium tuberculosis”. X-ray diffraction, 5 pockets (best druggability 0.88). MolNFT v1 #105628 on GenesisL1: 3D structure…

PDB: 4RAE
Type: protein
Length: 732 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histidinol-phosphate aminotransferase
EC: 2.6.1.9
UniProt: I6XYD8
Pockets: 5 · best druggability 0.88

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histidinol-phosphate aminotransferase (EC 2.6.1.9)	protein	367	42% helix, 15% strand	I6XYD8
B	Histidinol-phosphate aminotransferase (EC 2.6.1.9)	protein	365	41% helix, 17% strand	I6XYD8

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	691	0.88	0.93	96	empty
2	201	0.77	0.92	31	empty
3	607	0.69	0.78	57	empty
4	142	0.63	0.86	28	empty
5	84	0.60	0.89	18	empty

Interfaces

1 interface between chains.

A–B · 3525 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

4RAE · Crystal structure of Rv1600 encoded aminotransferase from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6XYD8
Elsewhere: RCSB PDB 4RAE · PDBe 4RAE · UniProt I6XYD8

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