MolNFT v1 · #105616 · protein

PP2CA

4RA2 · Protein phosphatase 1A: “PP2CA”. X-ray diffraction, 2 ligands (MN, PO4), 3 pockets (best druggability 0.45). MolNFT v1 #105616 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RA2
Type: protein
Length: 363 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein phosphatase 1A
EC: 3.1.3.16
UniProt: P35813
Ligands: MN, PO4
Pockets: 3 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein phosphatase 1A (EC 3.1.3.16)	protein	363	36% helix, 26% strand	P35813

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.45	0.78	17	empty
2	107	0.39	0.76	19	MN, PO4
3	82	0.35	0.75	18	empty

Compared structures

4RA2 · PP2Ca · the same entry in another collection · chain A against A, TM-score 1.00
P35813 · AlphaFold monomer V2.0 prediction for protein phosphatase 1A (P35813) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35813
Elsewhere: RCSB PDB 4RA2 · PDBe 4RA2 · UniProt P35813

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