MolNFT v1 · #105475 · protein
Structure of RAD6~UB
4R62 · Ubiquitin-conjugating enzyme E2 2: “Structure of RAD6~UB”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #105475 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4R62
- Type
- protein
- Length
- 227 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 2; Ubiquitin-40S ribosomal protein S27A
- EC
- 6.3.2.19
- UniProt
- P06104, P62979
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2 2 (EC 6.3.2.19) | protein | 149 | 38% helix, 20% strand | P06104 |
| B | Ubiquitin-40S ribosomal protein S27A | protein | 78 | 23% helix, 36% strand | P62979 |
Ligands and binding sites
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.38 | 0.75 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 254 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06104
- Every structure of UniProt P62979
- Elsewhere: RCSB PDB 4R62 · PDBe 4R62 · UniProt P06104 · UniProt P62979
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