MolNFT v1 · #105467 · protein

Crystal structure of rhodostomin R46E mutant

4R5U · Disintegrin rhodostomin: “Crystal structure of rhodostomin R46E mutant”. X-ray diffraction, 1 pocket (best druggability 0.59). MolNFT v1 #105467 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4R5U
Type: protein
Length: 128 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disintegrin rhodostomin
UniProt: P30403
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Disintegrin rhodostomin	protein	64	0% helix, 20% strand	P30403

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.59	0.80	26	empty

Interfaces

1 interface between chains.

A–B · 582 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

4R5U · Crystal structure of Rhodostomin R46E mutant · the same entry in another collection · chain A against A, TM-score 1.00
P30403 · AlphaFold monomer V2.0 prediction for zinc METALLOPROTEINASE/DISINTEGRIN (P30403) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30403
Elsewhere: RCSB PDB 4R5U · PDBe 4R5U · UniProt P30403

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.