MolNFT v1 · #105402 · protein
Crystal structure of human argrs-glnrs-AIMP1 complex
4R3Z · Aminoacyl tRNA synthase complex-interacting multifunctional…: “Crystal structure of human argrs-glnrs-AIMP1 complex”. X-ray diffraction, 18 pockets (best druggability 0.73). MolNFT v1 #105402 on GenesisL1: 3D structure, binding…
- PDB
- 4R3Z
- Type
- protein
- Length
- 1,273 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Arginine--tRNA…
- EC
- 6.1.1.19, 6.1.1.18
- UniProt
- Q12904, P54136, P47897
- Pockets
- 18 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 37% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 | protein | 76 | 71% helix, 0% strand | Q12904 |
| B | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) | protein | 659 | 43% helix, 8% strand | P54136 |
| C | Glutamine--tRNA ligase (EC 6.1.1.18) | protein | 538 | 24% helix, 17% strand | P47897 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.73 | 0.97 | 19 | empty |
| 2 | 187 | 0.66 | 0.85 | 23 | empty |
| 3 | 67 | 0.66 | 0.93 | 17 | empty |
| 4 | 308 | 0.62 | 0.79 | 43 | empty |
| 5 | 184 | 0.59 | 0.82 | 43 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1434 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 763 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 326 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4R3Z · Crystal structure of human ArgRS-GlnRS-AIMP1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P47897 · AlphaFold monomer V2.0 prediction for glutamine--tRNA ligase (P47897) · a predicted model of the same protein · chain C against A, TM-score 0.97
- P54136 · AlphaFold monomer V2.0 prediction for arginine--tRNA ligase, cytoplasmic (P54136) · a predicted model of the same protein · chain B against A, TM-score 0.90
- Q12904 · AlphaFold monomer V2.0 prediction for aminoacyl tRNA synthase complex-interacting… · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12904
- Every structure of UniProt P54136
- Every structure of UniProt P47897
- Elsewhere: RCSB PDB 4R3Z · PDBe 4R3Z · UniProt Q12904 · UniProt P54136 · UniProt P47897
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