MolNFT v1 · #105361 · protein
Crystal structure of R134D mutant of ynaf (universal stress protein F) from salmonella typhimurium
4R2M: “Crystal structure of R134D mutant of ynaf (universal stress protein F) from salmonella typhimurium”. X-ray diffraction, 2 ligands (ANP, MG), 2 pockets (best druggability 0.68). MolNFT v1 #105361 on GenesisL1: 3D structure, binding…
- PDB
- 4R2M
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Universal stress protein F
- UniProt
- P67091
- Ligands
- ANP, MG
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Universal stress protein F | protein | 142 | 42% helix, 21% strand | P67091 |
| B | Universal stress protein F | protein | 142 | 40% helix, 21% strand | P67091 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.68 | 0.81 | 51 | MG, ANP |
| 2 | 190 | 0.66 | 0.85 | 27 | MG, ANP |
Interfaces
1 interface between chains.
- A–B · 843 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4R2M · Crystal Structure of R134D mutant of YnaF (Universal Stress Protein F) from Salmonella… · the same entry in another collection · chain A against A, TM-score 1.00
- P67091 · AlphaFold monomer V2.0 prediction for universal stress protein F (P67091) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67091
- Elsewhere: RCSB PDB 4R2M · PDBe 4R2M · UniProt P67091
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