MolNFT v1 · #105350 · protein
Crystal structure of sugar transporter OANT_3817 from ochrobactrum anthropi, target efi-510528, with bound glucose
4R2B · Extracellular solute-binding protein family 1: “Crystal structure of sugar transporter OANT_3817 from ochrobactrum anthropi, target efi-510528, with bound…”. X-ray diffraction, 1 ligand (GLC), 5 pockets (best druggability 0.57).…
- PDB
- 4R2B
- Type
- protein
- Length
- 790 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Extracellular solute-binding protein family 1
- UniProt
- A6X5L9
- Ligands
- GLC
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Extracellular solute-binding protein family 1 | protein | 395 | 52% helix, 17% strand | A6X5L9 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 429 | 0.57 | 0.74 | 48 | empty |
| 2 | 78 | 0.46 | 0.82 | 22 | empty |
| 3 | 87 | 0.43 | 0.79 | 23 | empty |
| 4 | 53 | 0.27 | 0.73 | 12 | empty |
| 5 | 54 | 0.27 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 114 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4R2B · Crystal structure of sugar transporter Oant_3817 from Ochrobactrum anthropi, target… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6X5L9
- Elsewhere: RCSB PDB 4R2B · PDBe 4R2B · UniProt A6X5L9
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