MolNFT v1 · #105317 · protein
Crystal structure of 3D7 strain plasmodium falciparum AMA1
4R1C · Apical membrane antigen 1, AMA1: “Crystal structure of 3D7 strain plasmodium falciparum AMA1”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #105317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4R1C
- Type
- protein
- Length
- 541 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apical membrane antigen 1, AMA1
- UniProt
- Q7KQK5
- Pockets
- 3 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apical membrane antigen 1, AMA1 | protein | 279 | 16% helix, 30% strand | Q7KQK5 |
| B | Apical membrane antigen 1, AMA1 | protein | 262 | 17% helix, 30% strand | Q7KQK5 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.34 | 0.74 | 14 | empty |
| 2 | 68 | 0.28 | 0.72 | 18 | empty |
| 3 | 50 | 0.27 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 69 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4R1C · Crystal Structure of 3D7 strain Plasmodium falciparum AMA1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7KQK5
- Elsewhere: RCSB PDB 4R1C · PDBe 4R1C · UniProt Q7KQK5
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