MolNFT v1 · #105314 · protein

Crystal structure of 3D7 strain plasmodium falciparum AMA1

4R19 · Apical membrane antigen 1, AMA1: “Crystal structure of 3D7 strain plasmodium falciparum AMA1”. X-ray diffraction, 7 pockets (best druggability 0.75). MolNFT v1 #105314 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4R19
Type: protein
Length: 638 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apical membrane antigen 1, AMA1
UniProt: Q7KQK5
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apical membrane antigen 1, AMA1	protein	321	17% helix, 27% strand	Q7KQK5
B	Apical membrane antigen 1, AMA1	protein	317	17% helix, 26% strand	Q7KQK5

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1089	0.75	0.77	88	empty
2	204	0.58	0.80	24	empty
3	139	0.51	0.79	24	empty
4	110	0.47	0.79	13	empty
5	94	0.42	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 533 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

4R19 · Crystal Structure of 3D7 strain Plasmodium falciparum AMA1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7KQK5
Elsewhere: RCSB PDB 4R19 · PDBe 4R19 · UniProt Q7KQK5

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