MolNFT v1 · #105304 · protein
Structure of maltose-binding protein fusion with the C-terminal GH1 domain of guanylate kinase-associated protein from rattus norvegicus
4R0Y · Maltose-binding periplasmic protein, disks large-associated…: “Structure of maltose-binding protein fusion with the C-terminal GH1 domain of guanylate kinase-associated…”. X-ray diffraction, 13 pockets (best druggability 0.65).…
- PDB
- 4R0Y
- Type
- protein
- Length
- 942 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, disks large-associated protein 1
- UniProt
- P0AEX9, P97836
- Pockets
- 13 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, disks large-associated protein 1 | protein | 469 | 53% helix, 16% strand | P0AEX9, P97836 |
| B | Maltose-binding periplasmic protein, disks large-associated protein 1 | protein | 473 | 52% helix, 15% strand | P0AEX9, P97836 |
Pockets
13 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.65 | 0.88 | 25 | empty |
| 2 | 54 | 0.61 | 0.93 | 16 | empty |
| 3 | 261 | 0.61 | 0.80 | 28 | empty |
| 4 | 152 | 0.60 | 0.84 | 19 | empty |
| 5 | 338 | 0.59 | 0.76 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 698 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4R0Y · Structure of Maltose-binding Protein Fusion with the C-terminal GH1 domain of Guanylate… · the same entry in another collection · chain A against A, TM-score 1.00
- P97836 · AlphaFold monomer V2.0 prediction for disks large-associated protein 1 (P97836) · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P97836
- Elsewhere: RCSB PDB 4R0Y · PDBe 4R0Y · UniProt P0AEX9 · UniProt P97836
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