MolNFT v1 · #105287 · protein
Crystal structure of LPG0393 from legionella pneumophila
4R0G · Uncharacterized protein: “Crystal structure of LPG0393 from legionella pneumophila”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #105287 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4R0G
- Type
- protein
- Length
- 995 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- Q5ZYH9
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 253 | 74% helix, 0% strand | Q5ZYH9 |
| B | Uncharacterized protein | protein | 240 | 77% helix, 0% strand | Q5ZYH9 |
| C | Uncharacterized protein | protein | 252 | 75% helix, 0% strand | Q5ZYH9 |
| D | Uncharacterized protein | protein | 250 | 74% helix, 0% strand | Q5ZYH9 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 687 | 0.79 | 0.84 | 74 | empty |
| 2 | 832 | 0.74 | 0.78 | 51 | empty |
| 3 | 283 | 0.68 | 0.83 | 42 | empty |
| 4 | 203 | 0.59 | 0.81 | 28 | empty |
| 5 | 166 | 0.54 | 0.80 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1600 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1576 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 845 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 471 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 228 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4R0G · Crystal structure of Lpg0393 from Legionella pneumophila · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZYH9
- Elsewhere: RCSB PDB 4R0G · PDBe 4R0G · UniProt Q5ZYH9
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