MolNFT v1 · #105235 · protein
The crystal structures of holo-wt human cellular retinol binding protein II (hcrbpii) bound to retinol
4QYN · Retinol-binding protein 2: “The crystal structures of holo-wt human cellular retinol binding protein II (hcrbpii) bound to retinol”. X-ray diffraction, 1 ligand (RTL), 4 pockets (best druggability 0.84). MolNFT v1 #105235 on…
- PDB
- 4QYN
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinol-binding protein 2
- UniProt
- P50120
- Ligands
- RTL
- Pockets
- 4 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Retinol-binding protein 2 | protein | 133 | 11% helix, 55% strand | P50120 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.84 | 0.95 | 37 | RTL |
| 2 | 271 | 0.82 | 0.94 | 33 | RTL |
| 3 | 149 | 0.55 | 0.81 | 34 | empty |
| 4 | 65 | 0.35 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 771 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4QYN · The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII)… · the same entry in another collection · chain A against A, TM-score 1.00
- P50120 · AlphaFold monomer V2.0 prediction for retinol-binding protein 2 (P50120) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50120
- Elsewhere: RCSB PDB 4QYN · PDBe 4QYN · UniProt P50120
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