MolNFT v1 · #10519 · protein
Crystal structure of human GAMMA1-adaptin ear domain
1IU1: “Crystal structure of human GAMMA1-adaptin ear domain”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #10519 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1IU1
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GAMMA1-adaptin
- UniProt
- O43747
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GAMMA1-adaptin | protein | 120 | 5% helix, 53% strand | O43747 |
| B | GAMMA1-adaptin | protein | 123 | 5% helix, 51% strand | O43747 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.34 | 0.77 | 22 | empty |
| 2 | 55 | 0.32 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 691 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43747
- Elsewhere: RCSB PDB 1IU1 · PDBe 1IU1 · UniProt O43747
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