MolNFT v1 · #105132 · protein
Unliganded crystal structure of feline norovirus P domain co- crystallized with N-acetylneuraminic acid
4QVJ · VP1: “Unliganded crystal structure of feline norovirus P domain co- crystallized with N-acetylneuraminic acid”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #105132 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4QVJ
- Type
- protein
- Length
- 622 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP1
- UniProt
- H8YRY9
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | VP1 | protein | 311 | 6% helix, 36% strand | H8YRY9 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 367 | 0.81 | 0.90 | 68 | empty |
| 2 | 191 | 0.56 | 0.80 | 25 | empty |
| 3 | 126 | 0.52 | 0.81 | 18 | empty |
| 4 | 134 | 0.41 | 0.75 | 22 | empty |
| 5 | 114 | 0.38 | 0.74 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 2036 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
- 4QVJ · Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H8YRY9
- Elsewhere: RCSB PDB 4QVJ · PDBe 4QVJ · UniProt H8YRY9
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