MolNFT v1 · #10513 · protein
Dimeric form of the haemopexin domain of MMP9
1ITV: “Dimeric form of the haemopexin domain of MMP9”. X-ray diffraction, 1 ligand (SO4), 6 pockets (best druggability 0.51). MolNFT v1 #10513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1ITV
- Type
- protein
- Length
- 390 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MMP9
- EC
- 3.4.24.35
- UniProt
- P14780
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | MMP9 (EC 3.4.24.35) | protein | 195 | 9% helix, 45% strand | P14780 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.51 | 0.84 | 16 | empty |
| 2 | 107 | 0.39 | 0.76 | 17 | empty |
| 3 | 82 | 0.37 | 0.76 | 14 | empty |
| 4 | 69 | 0.36 | 0.77 | 18 | empty |
| 5 | 78 | 0.33 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 697 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14780
- Elsewhere: RCSB PDB 1ITV · PDBe 1ITV · UniProt P14780
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