MolNFT v1 · #105112 · protein

Crystal structure of feline norovirus P domain

4QUZ · VP1: “Crystal structure of feline norovirus P domain”. X-ray diffraction, 6 pockets (best druggability 0.83). MolNFT v1 #105112 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QUZ
Type: protein
Length: 629 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP1
UniProt: H8YRY9
Pockets: 6 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP1	protein	311	6% helix, 34% strand	H8YRY9
B	VP1	protein	318	9% helix, 33% strand	H8YRY9

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	443	0.83	0.90	74	empty
2	223	0.58	0.79	30	EDO
3	134	0.50	0.79	18	empty
4	124	0.38	0.74	21	empty
5	98	0.34	0.73	17	EDO

Interfaces

1 interface between chains.

A–B · 1984 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

4QUZ · Crystal structure of Feline Norovirus P Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H8YRY9
Elsewhere: RCSB PDB 4QUZ · PDBe 4QUZ · UniProt H8YRY9

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