MolNFT v1 · #105084 · protein + RNA
Crystal structure of a G-rich RNA sequence binding factor 1 (GRSF1) from homo sapiens at 2.50 a resolution
4QU7 · G-rich sequence factor 1: “Crystal structure of a G-rich RNA sequence binding factor 1 (GRSF1) from homo sapiens at 2.50 a resolution”. X-ray diffraction, 1 pocket (best druggability 0.68). MolNFT v1 #105084 on GenesisL1: 3D…
- PDB
- 4QU7
- Type
- protein + RNA
- Length
- 326 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-rich sequence factor 1; RNA 5'-(*AP*GP*GP*GP*AP*UP)-3'
- UniProt
- Q12849
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 5 distinct chains · 23% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-rich sequence factor 1 | protein | 81 | 22% helix, 36% strand | Q12849 |
| B, C | G-rich sequence factor 1 | protein | 79 | 23% helix, 39% strand | Q12849 |
| D | G-rich sequence factor 1 | protein | 77 | 23% helix, 40% strand | Q12849 |
| U, X | RNA 5'-(*AP*GP*GP*GP*AP*UP)-3' | rna | 3 | — | — |
| V | RNA 5'-(*AP*GP*GP*GP*AP*UP)-3' | rna | 4 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 854 | 0.68 | 0.75 | 68 | empty |
Interfaces
8 interfaces between chains.
- A–B · 606 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 592 Ų buried · 14 hydrogen bonds · protein-protein
- B–V · 437 Ų buried · 20 hydrogen bonds · protein-nucleic
- A–U · 392 Ų buried · 13 hydrogen bonds · protein-nucleic
- D–X · 377 Ų buried · 19 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4QU7 · Crystal structure of a G-rich RNA sequence binding factor 1 (GRSF1) from Homo sapiens at… · the same entry in another collection · chain X against X, TM-score 1.00
- Q12849 · AlphaFold monomer V2.0 prediction for G-rich sequence factor 1 (Q12849) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12849
- Elsewhere: RCSB PDB 4QU7 · PDBe 4QU7 · UniProt Q12849
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