MolNFT v1 · #105049 · protein
Crystal structure of 3BD10: a monoclonal antibody against the tsh receptor
4QT5 · 3BD10 mouse monoclonal antibody, light chain: “Crystal structure of 3BD10: a monoclonal antibody against the tsh receptor”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #105049 on GenesisL1: 3D structure, binding…
- PDB
- 4QT5
- Type
- protein
- Length
- 846 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3BD10 mouse monoclonal antibody, light chain; 3BD10 mouse monoclonal antibody, heavy chain
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | 3BD10 mouse monoclonal antibody, light chain | protein | 216 | 6% helix, 52% strand | — |
| H, B | 3BD10 mouse monoclonal antibody, heavy chain | protein | 207 | 10% helix, 53% strand | — |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 945 | 0.80 | 0.82 | 98 | empty |
| 2 | 917 | 0.75 | 0.79 | 103 | empty |
| 3 | 324 | 0.71 | 0.84 | 32 | empty |
| 4 | 223 | 0.61 | 0.81 | 27 | empty |
| 5 | 222 | 0.60 | 0.80 | 25 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1645 Ų buried · 9 hydrogen bonds · protein-protein
- L–H · 1625 Ų buried · 12 hydrogen bonds · protein-protein
- L–A · 829 Ų buried · 7 hydrogen bonds · protein-protein
- H–A · 133 Ų buried · 0 hydrogen bonds · protein-protein
- L–B · 126 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4QT5 · Crystal Structure of 3BD10: A Monoclonal Antibody against the TSH Receptor · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4QT5 · PDBe 4QT5
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