MolNFT v1 · #105011 · protein
Crystal structure of pro-papain mutant at pH 4.0
4QRX: “Crystal structure of pro-papain mutant at pH 4.0”. X-ray diffraction, 3 pockets (best druggability 0.57). MolNFT v1 #105011 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4QRX
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pro-papain
- EC
- 3.4.22.2
- UniProt
- P00784
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pro-papain (EC 3.4.22.2) | protein | 292 | 33% helix, 18% strand | P00784 |
| C | Pro-papain (EC 3.4.22.2) | protein | 307 | 29% helix, 17% strand | P00784 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.57 | 0.86 | 20 | empty |
| 2 | 56 | 0.35 | 0.78 | 13 | empty |
| 3 | 58 | 0.31 | 0.76 | 12 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00784
- Elsewhere: RCSB PDB 4QRX · PDBe 4QRX · UniProt P00784
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