MolNFT v1 · #104981 · protein
Crystal structure of streptococcus pyogenes CAS2 at pH 7.5
4QR2 · CRISPR-associated endoribonuclease CAS2: “Crystal structure of streptococcus pyogenes CAS2 at pH 7.5”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #104981 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4QR2
- Type
- protein
- Length
- 165 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated endoribonuclease CAS2
- EC
- 3.1.-.-
- UniProt
- Q99YS8
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR-associated endoribonuclease CAS2 (EC 3.1.-.-) | protein | 83 | 39% helix, 34% strand | Q99YS8 |
| B | CRISPR-associated endoribonuclease CAS2 (EC 3.1.-.-) | protein | 82 | 40% helix, 33% strand | Q99YS8 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.58 | 0.84 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1485 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 4QR2 · Crystal structure of Streptococcus pyogenes Cas2 at pH 7.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99YS8
- Elsewhere: RCSB PDB 4QR2 · PDBe 4QR2 · UniProt Q99YS8
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