MolNFT v1 · #104943 · protein

Crystal structure of C1QL2

4QPY · Complement C1Q-like protein 2: “Crystal structure of C1QL2”. X-ray diffraction, 2 pockets (best druggability 0.81). MolNFT v1 #104943 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QPY
Type: protein
Length: 396 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement C1Q-like protein 2
UniProt: Q8CFR0
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Complement C1Q-like protein 2	protein	131	0% helix, 56% strand	Q8CFR0
B	Complement C1Q-like protein 2	protein	134	0% helix, 55% strand	Q8CFR0

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	412	0.81	0.90	64	empty
2	53	0.49	0.86	18	empty

Interfaces

3 interfaces between chains.

B–C · 1010 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 949 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 881 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4QPY · Crystal structure of C1QL2 · the same entry in another collection · chain A against A, TM-score 1.00
Q8CFR0 · AlphaFold monomer V2.0 prediction for complement C1Q-like protein 2 (Q8CFR0) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CFR0
Elsewhere: RCSB PDB 4QPY · PDBe 4QPY · UniProt Q8CFR0

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