MolNFT v1 · #104933 · protein
Crystal structure of human methyltransferase-like protein 21B
4QPN · Protein-lysine methyltransferase METTL21B: “Crystal structure of human methyltransferase-like protein 21B”. X-ray diffraction, 3 ligands (SAH, UNX, SO4), 1 pocket (best druggability 0.65). MolNFT v1 #104933 on GenesisL1: 3D…
- PDB
- 4QPN
- Type
- protein
- Length
- 203 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-lysine methyltransferase METTL21B
- EC
- 2.1.1.-
- UniProt
- Q96AZ1
- Ligands
- SAH, UNX, SO4
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-lysine methyltransferase METTL21B (EC 2.1.1.-) | protein | 203 | 34% helix, 34% strand | Q96AZ1 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
- UNX · Unknown atom or ion · ion · 14 copies · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.65 | 0.83 | 35 | SAH, UNX |
Compared structures
- 4QPN · Crystal Structure of Human Methyltransferase-Like Protein 21B · the same entry in another collection · chain A against A, TM-score 1.00
- Q96AZ1 · AlphaFold monomer V2.0 prediction for EEF1A lysine methyltransferase 3 (Q96AZ1) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96AZ1
- Elsewhere: RCSB PDB 4QPN · PDBe 4QPN · UniProt Q96AZ1
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