MolNFT v1 · #104881 · protein
Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
4QO3 · Fibroblast growth factor 1: “Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor”. X-ray diffraction, 3 pockets (best druggability 0.37). MolNFT v1 #104881 on GenesisL1: 3D structure…
- PDB
- 4QO3
- Type
- protein
- Length
- 283 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 1
- UniProt
- P05230
- Pockets
- 3 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor 1 | protein | 142 | 8% helix, 37% strand | P05230 |
| B | Fibroblast growth factor 1 | protein | 141 | 6% helix, 38% strand | P05230 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.37 | 0.75 | 21 | empty |
| 2 | 83 | 0.36 | 0.75 | 26 | empty |
| 3 | 65 | 0.34 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 460 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4QO3 · Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 4QO3 · PDBe 4QO3 · UniProt P05230
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