MolNFT v1 · #10485 · protein
Crystal structure of xylanase from streptomyces olivaceoviridis E-86 complexed with xylobiose
1ISW · Endo-1,4-beta-D-xylanase: “Crystal structure of xylanase from streptomyces olivaceoviridis E-86 complexed with xylobiose”. X-ray diffraction, 1 ligand (XYP), 4 pockets (best druggability 0.72). MolNFT v1 #10485 on GenesisL1: 3D…
- PDB
- 1ISW
- Type
- protein
- Length
- 872 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endo-1,4-beta-D-xylanase
- EC
- 3.2.1.8
- UniProt
- Q7SI98
- Ligands
- XYP
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Endo-1,4-beta-D-xylanase (EC 3.2.1.8) | protein | 436 | 32% helix, 24% strand | Q7SI98 |
Ligands and binding sites
- XYP · beta-D-xylopyranose · sugar · 14 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1007 | 0.72 | 0.76 | 106 | empty |
| 2 | 381 | 0.66 | 0.80 | 50 | empty |
| 3 | 78 | 0.36 | 0.76 | 18 | XYP |
| 4 | 69 | 0.34 | 0.77 | 18 | XYP |
Interfaces
1 interface between chains.
- A–B · 1047 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1ISW · Crystal structure of xylanase from Streptomyces olivaceoviridis E-86 complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SI98
- Elsewhere: RCSB PDB 1ISW · PDBe 1ISW · UniProt Q7SI98
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