MolNFT v1 · #104790 · protein
Crystal structure of juvenile hormone epoxide hydrolase from the silkworm bombyx mori
4QLA: “Crystal structure of juvenile hormone epoxide hydrolase from the silkworm bombyx mori”. X-ray diffraction, 7 pockets (best druggability 0.79). MolNFT v1 #104790 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4QLA
- Type
- protein
- Length
- 804 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Juvenile hormone epoxide hydrolase
- EC
- 3.3.2.9
- UniProt
- H9JWL6
- Pockets
- 7 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Juvenile hormone epoxide hydrolase (EC 3.3.2.9) | protein | 424 | 47% helix, 13% strand | H9JWL6 |
| B | Juvenile hormone epoxide hydrolase (EC 3.3.2.9) | protein | 380 | 42% helix, 15% strand | H9JWL6 |
Ligands and binding sites
- 1PE · Pentaethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.79 | 0.84 | 60 | empty |
| 2 | 321 | 0.61 | 0.78 | 38 | empty |
| 3 | 129 | 0.50 | 0.80 | 15 | empty |
| 4 | 145 | 0.41 | 0.74 | 32 | empty |
| 5 | 127 | 0.39 | 0.74 | 17 | 1PE |
Interfaces
1 interface between chains.
- A–B · 2456 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 4QLA · Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H9JWL6
- Elsewhere: RCSB PDB 4QLA · PDBe 4QLA · UniProt H9JWL6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.