MolNFT v1 · #10476 · protein

Crystal structure of merlin ferm domain

1ISN: “Crystal structure of merlin ferm domain”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #10476 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ISN
Type: protein
Length: 323 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Merlin
UniProt: P46662
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Merlin	protein	323	38% helix, 21% strand	P46662

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.57	0.76	27	empty
2	281	0.56	0.76	34	empty
3	78	0.44	0.80	22	empty
4	70	0.38	0.78	17	empty
5	50	0.33	0.78	13	empty

Compared structures

1ISN · Crystal structure of merlin FERM domain · the same entry in another collection · chain A against A, TM-score 1.00
P46662 · AlphaFold monomer V2.0 prediction for merlin (P46662) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46662
Elsewhere: RCSB PDB 1ISN · PDBe 1ISN · UniProt P46662

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