MolNFT v1 · #10474 · protein

3-oxo-DELTA5-steroid isomerase, NMR, 20 structures

1ISK: “3-oxo-DELTA5-steroid isomerase, NMR, 20 structures”. Solution nmr, 4 pockets (best druggability 0.66). MolNFT v1 #10474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ISK
Type: protein
Length: 250 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-oxo-DELTA5-steroid isomerase
EC: 5.3.3.1
UniProt: P00947
Pockets: 4 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 32% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	3-oxo-DELTA5-steroid isomerase (EC 5.3.3.1)	protein	125	32% helix, 42% strand	P00947

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.66	0.83	28	empty
2	192	0.63	0.83	25	empty
3	83	0.42	0.79	23	empty
4	78	0.33	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 857 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

1ISK · 3-oxo-DELTA5-steroid isomerase, NMR, 20 structures · the same entry in another collection · chain B against B, TM-score 1.00
P00947 · AlphaFold monomer V2.0 prediction for steroid delta-isomerase (P00947) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00947
Elsewhere: RCSB PDB 1ISK · PDBe 1ISK · UniProt P00947

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