MolNFT v1 · #104739 · protein

Crystal structure of apo nucleoid associated protein, SAV1473

4QJN · DNA-binding protein hu: “Crystal structure of apo nucleoid associated protein, SAV1473”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #104739 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QJN
Type: protein
Length: 360 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-binding protein hu
UniProt: Q99U17
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	DNA-binding protein hu	protein	90	43% helix, 31% strand	Q99U17

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.54	0.78	33	empty

Interfaces

5 interfaces between chains.

A–C · 1955 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 1942 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 216 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 102 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 80 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4QJN · Crystal structure of apo nucleoid associated protein, SAV1473 · the same entry in another collection · chain D against D, TM-score 1.00
Q99U17 · AlphaFold monomer V2.0 prediction for DNA-binding protein hu (Q99U17) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99U17
Elsewhere: RCSB PDB 4QJN · PDBe 4QJN · UniProt Q99U17

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