MolNFT v1 · #104625 · protein
Crystal structure of mutant ribosomal protein G219V TTHL1
4QGB · 50S ribosomal protein L1: “Crystal structure of mutant ribosomal protein G219V TTHL1”. X-ray diffraction, 1 ligand (CL), 5 pockets (best druggability 0.75). MolNFT v1 #104625 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4QGB
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 50S ribosomal protein L1
- UniProt
- P27150
- Ligands
- CL
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 50S ribosomal protein L1 | protein | 216 | 34% helix, 22% strand | P27150 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 645 | 0.75 | 0.81 | 85 | empty |
| 2 | 175 | 0.70 | 0.88 | 35 | empty |
| 3 | 120 | 0.49 | 0.80 | 25 | empty |
| 4 | 104 | 0.41 | 0.77 | 21 | empty |
| 5 | 68 | 0.33 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1439 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27150
- Elsewhere: RCSB PDB 4QGB · PDBe 4QGB · UniProt P27150
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