MolNFT v1 · #104420 · protein
Crystal structure of TIPE3
4Q9V · Tumor necrosis factor alpha-induced protein 8-like protein 3: “Crystal structure of TIPE3”. X-ray diffraction, 2 ligands (SO4, CL), 4 pockets (best druggability 0.84). MolNFT v1 #104420 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4Q9V
- Type
- protein
- Length
- 369 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor alpha-induced protein 8-like protein 3
- UniProt
- Q5GJ75
- Ligands
- SO4, CL
- Pockets
- 4 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor necrosis factor alpha-induced protein 8-like protein 3 | protein | 183 | 83% helix, 0% strand | Q5GJ75 |
| B | Tumor necrosis factor alpha-induced protein 8-like protein 3 | protein | 186 | 80% helix, 0% strand | Q5GJ75 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 582 | 0.84 | 0.88 | 45 | empty |
| 2 | 609 | 0.83 | 0.87 | 43 | empty |
| 3 | 421 | 0.65 | 0.78 | 32 | SO4 |
| 4 | 194 | 0.52 | 0.77 | 22 | CL |
Interfaces
1 interface between chains.
- A–B · 1651 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5GJ75
- Elsewhere: RCSB PDB 4Q9V · PDBe 4Q9V · UniProt Q5GJ75
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