MolNFT v1 · #104418 · protein

Crystal structure of vanderwaltozyma polyspora NUP133 beta-propeller domain

4Q9T · Nucleoporin NUP133: “Crystal structure of vanderwaltozyma polyspora NUP133 beta-propeller domain”. X-ray diffraction, 11 pockets (best druggability 0.78). MolNFT v1 #104418 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4Q9T
Type: protein
Length: 766 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP133
UniProt: A7TDS5
Pockets: 11 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP133	protein	384	5% helix, 48% strand	A7TDS5
B	Nucleoporin NUP133	protein	382	5% helix, 50% strand	A7TDS5

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	891	0.78	0.81	73	empty
2	1155	0.78	0.80	85	empty
3	348	0.61	0.78	34	empty
4	125	0.52	0.81	29	empty
5	128	0.48	0.79	22	empty

Interfaces

1 interface between chains.

A–B · 894 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

4Q9T · Crystal structure of Vanderwaltozyma polyspora Nup133 Beta-propeller domain · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A7TDS5
Elsewhere: RCSB PDB 4Q9T · PDBe 4Q9T · UniProt A7TDS5

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