MolNFT v1 · #104405 · protein
Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
4Q9G · Fibroblast growth factor 1: “Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor”. X-ray diffraction, 1 ligand (PO4), 3 pockets (best druggability 0.40). MolNFT v1 #104405 on GenesisL1: 3D…
- PDB
- 4Q9G
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 1
- UniProt
- P05230
- Ligands
- PO4
- Pockets
- 3 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fibroblast growth factor 1 | protein | 142 | 11% helix, 37% strand | P05230 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.40 | 0.76 | 19 | empty |
| 2 | 52 | 0.34 | 0.78 | 18 | empty |
| 3 | 50 | 0.29 | 0.75 | 12 | FMT |
Interfaces
1 interface between chains.
- A–B · 456 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4Q9G · Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 4Q9G · PDBe 4Q9G · UniProt P05230
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