MolNFT v1 · #104394 · protein
Crystal structure of HRASLS3/LRAT chimeric protein
4Q95 · HRAS-like suppressor 3, lecithin retinol acyltransferase: “Crystal structure of HRASLS3/LRAT chimeric protein”. X-ray diffraction, 1 ligand (SHV), 4 pockets (best druggability 0.44). MolNFT v1 #104394 on GenesisL1: 3D structure…
- PDB
- 4Q95
- Type
- protein
- Length
- 268 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HRAS-like suppressor 3, lecithin retinol acyltransferase
- EC
- 2.3.1.135
- UniProt
- P53816, Q9JI60
- Ligands
- SHV
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HRAS-like suppressor 3, lecithin retinol acyltransferase (EC 2.3.1.135) | protein | 141 | 23% helix, 39% strand | P53816, Q9JI60 |
| B | HRAS-like suppressor 3, lecithin retinol acyltransferase (EC 2.3.1.135) | protein | 127 | 22% helix, 43% strand | P53816, Q9JI60 |
Ligands and binding sites
- SHV · Heptanoic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.44 | 0.83 | 14 | SHV |
| 2 | 62 | 0.42 | 0.81 | 16 | SHV |
| 3 | 115 | 0.38 | 0.74 | 20 | empty |
| 4 | 81 | 0.32 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2574 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 4Q95 · Crystal structure of HRASLS3/LRAT chimeric protein · the same entry in another collection · chain A against A, TM-score 1.00
- P53816 · AlphaFold monomer V2.0 prediction for phospholipase a and acyltransferase 3 (P53816) · a predicted model of the same protein · chain B against A, TM-score 0.66
- Q9JI60 · AlphaFold monomer V2.0 prediction for lecithin retinol acyltransferase (Q9JI60) · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53816
- Every structure of UniProt Q9JI60
- Elsewhere: RCSB PDB 4Q95 · PDBe 4Q95 · UniProt P53816 · UniProt Q9JI60
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