MolNFT v1 · #104353 · protein
Neutrophil serine protease 4 (PRSS57) apo form 1
4Q7X · Serine protease 57: “Neutrophil serine protease 4 (PRSS57) apo form 1”. X-ray diffraction, 2 ligands (NAG, FUC), 5 pockets (best druggability 0.72). MolNFT v1 #104353 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4Q7X
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine protease 57
- EC
- 3.4.21.-
- UniProt
- Q6UWY2
- Ligands
- NAG, FUC
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine protease 57 (EC 3.4.21.-) | protein | 235 | 11% helix, 35% strand | Q6UWY2 |
| B | Serine protease 57 (EC 3.4.21.-) | protein | 232 | 12% helix, 35% strand | Q6UWY2 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
- FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 898 | 0.72 | 0.76 | 70 | GOL |
| 2 | 76 | 0.33 | 0.74 | 16 | empty |
| 3 | 53 | 0.29 | 0.75 | 18 | empty |
| 4 | 61 | 0.29 | 0.74 | 18 | empty |
| 5 | 61 | 0.29 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 504 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UWY2
- Elsewhere: RCSB PDB 4Q7X · PDBe 4Q7X · UniProt Q6UWY2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.