MolNFT v1 · #104334 · protein

Non-phosphorylated hemr receiver domain from leptospira biflexa

4Q7E · Response regulator of a two component regulatory system: “Non-phosphorylated hemr receiver domain from leptospira biflexa”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.59). MolNFT v1 #104334 on GenesisL1: 3D…

PDB: 4Q7E
Type: protein
Length: 249 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator of a two component regulatory system
UniProt: B0SGG3
Ligands: SO4
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Response regulator of a two component regulatory system	protein	125	43% helix, 22% strand	B0SGG3
B	Response regulator of a two component regulatory system	protein	124	42% helix, 22% strand	B0SGG3

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B
GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.59	0.79	42	empty

Interfaces

1 interface between chains.

A–B · 850 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4Q7E · Non-phosphorylated HemR Receiver Domain from Leptospira biflexa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0SGG3
Elsewhere: RCSB PDB 4Q7E · PDBe 4Q7E · UniProt B0SGG3

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