MolNFT v1 · #104276 · protein

Crystal structure of the gluthatione S-transferase blo T 8

4Q5N · Gluthatione S-transferase blo T 8 isoform: “Crystal structure of the gluthatione S-transferase blo T 8”. X-ray diffraction, 1 ligand (GSH), 2 pockets (best druggability 0.79). MolNFT v1 #104276 on GenesisL1: 3D structure, binding…

PDB: 4Q5N
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gluthatione S-transferase blo T 8 isoform
UniProt: C8CGT7
Ligands: GSH
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gluthatione S-transferase blo T 8 isoform	protein	220	53% helix, 9% strand	C8CGT7
B	Gluthatione S-transferase blo T 8 isoform	protein	218	52% helix, 8% strand	C8CGT7

Ligands and binding sites

GSH · Glutathione · ligand · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1037	0.79	0.81	90	GSH
2	92	0.41	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 1422 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

4Q5N · Crystal structure of the gluthatione S-transferase Blo t 8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C8CGT7
Elsewhere: RCSB PDB 4Q5N · PDBe 4Q5N · UniProt C8CGT7

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