MolNFT v1 · #104230 · protein

Structure of the recq catalytic core from deinococcus radiodurans

4Q48 · DNA helicase recq: “Structure of the recq catalytic core from deinococcus radiodurans”. X-ray diffraction, 1 ligand (ZN), 8 pockets (best druggability 0.81). MolNFT v1 #104230 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4Q48
Type: protein
Length: 1,001 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA helicase recq
UniProt: Q9RUU2
Ligands: ZN
Pockets: 8 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA helicase recq	protein	500	46% helix, 16% strand	Q9RUU2
B	DNA helicase recq	protein	501	44% helix, 15% strand	Q9RUU2

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1100	0.81	0.82	103	empty
2	718	0.80	0.84	82	empty
3	581	0.70	0.79	59	empty
4	171	0.65	0.86	34	empty
5	86	0.60	0.88	14	empty

Interfaces

1 interface between chains.

A–B · 1334 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4Q48 · Structure of the RecQ Catalytic Core from Deinococcus radiodurans · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9RUU2
Elsewhere: RCSB PDB 4Q48 · PDBe 4Q48 · UniProt Q9RUU2

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