MolNFT v1 · #104151 · protein
Crystal structure of a C-terminal part of tyrosine kinase (divl) from caulobacter crescentus CB15 at 2.50 a resolution (psi community target, shapiro)
4Q20 · Sensor protein divl: “Crystal structure of a C-terminal part of tyrosine kinase (divl) from caulobacter crescentus CB15 at 2.50 a…”. X-ray diffraction, 7 pockets (best druggability 0.58). MolNFT v1 #104151 on GenesisL1: 3D…
- PDB
- 4Q20
- Type
- protein
- Length
- 456 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein divl
- EC
- 2.7.13.3
- UniProt
- Q9RQQ9
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein divl (EC 2.7.13.3) | protein | 231 | 55% helix, 19% strand | Q9RQQ9 |
| B | Sensor protein divl (EC 2.7.13.3) | protein | 225 | 54% helix, 20% strand | Q9RQQ9 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 261 | 0.58 | 0.78 | 32 | empty |
| 2 | 62 | 0.50 | 0.86 | 18 | empty |
| 3 | 112 | 0.50 | 0.81 | 15 | empty |
| 4 | 157 | 0.47 | 0.77 | 30 | empty |
| 5 | 148 | 0.41 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1660 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 4Q20 · Crystal structure of a C-terminal part of tyrosine kinase (DivL) from Caulobacter… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9RQQ9 · AlphaFold monomer V2.0 prediction for sensor protein divl (Q9RQQ9) · a predicted model of the same protein · chain B against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RQQ9
- Elsewhere: RCSB PDB 4Q20 · PDBe 4Q20 · UniProt Q9RQQ9
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