MolNFT v1 · #104102 · protein
Crystal structure of pyrococcus furiosus L-asparaginase
4Q0M: “Crystal structure of pyrococcus furiosus L-asparaginase”. X-ray diffraction, 2 ligands (4CS, PO4), 1 pocket (best druggability 0.48). MolNFT v1 #104102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4Q0M
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase
- EC
- 3.5.1.1
- UniProt
- Q8TZE8
- Ligands
- 4CS, PO4
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-asparaginase (EC 3.5.1.1) | protein | 327 | 29% helix, 24% strand | Q8TZE8 |
Ligands and binding sites
- 4CS · (4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid · ligand · chains A
- PO4 · Phosphate ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.48 | 0.82 | 24 | GOL |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TZE8
- Elsewhere: RCSB PDB 4Q0M · PDBe 4Q0M · UniProt Q8TZE8
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