MolNFT v1 · #104074 · protein
Crystal structure of a putative uncharacterize protein RV3404C and likely sugar N-formyltransferase from mycobacterium tuberculosis
4PZU · Uncharacterized protein RV3404C/MT3512: “Crystal structure of a putative uncharacterize protein RV3404C and likely sugar N-formyltransferase from…”. X-ray diffraction, 20 pockets (best druggability 0.64). MolNFT v1 #104074 on…
- PDB
- 4PZU
- Type
- protein
- Length
- 1,867 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein RV3404C/MT3512
- UniProt
- P65073
- Pockets
- 20 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, F | Uncharacterized protein RV3404C/MT3512 | protein | 235 | 35% helix, 25% strand | P65073 |
| B, E, G | Uncharacterized protein RV3404C/MT3512 | protein | 232 | 35% helix, 25% strand | P65073 |
| H | Uncharacterized protein RV3404C/MT3512 | protein | 231 | 35% helix, 25% strand | P65073 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 22 copies · chains A, B, C, D, E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.64 | 0.80 | 42 | empty |
| 2 | 265 | 0.62 | 0.80 | 42 | empty |
| 3 | 364 | 0.62 | 0.78 | 45 | empty |
| 4 | 326 | 0.61 | 0.78 | 45 | empty |
| 5 | 282 | 0.61 | 0.79 | 38 | EDO |
Interfaces
14 interfaces between chains.
- A–B · 1730 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1709 Ų buried · 31 hydrogen bonds · protein-protein
- E–F · 1689 Ų buried · 32 hydrogen bonds · protein-protein
- G–H · 1591 Ų buried · 28 hydrogen bonds · protein-protein
- C–E · 500 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4PZU · Crystal structure of a putative uncharacterize protein Rv3404c and likely sugar… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P65073
- Elsewhere: RCSB PDB 4PZU · PDBe 4PZU · UniProt P65073
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