MolNFT v1 · #10395 · protein
Crystal structure of the extracellular domain of mouse rank ligand
1IQA · Receptor activator of nuclear factor kappa B ligand: “Crystal structure of the extracellular domain of mouse rank ligand”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #10395 on GenesisL1: 3D structure, binding…
- PDB
- 1IQA
- Type
- protein
- Length
- 468 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor activator of nuclear factor kappa B ligand
- UniProt
- O35235
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Receptor activator of nuclear factor kappa B ligand | protein | 156 | 4% helix, 56% strand | O35235 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.74 | 0.99 | 14 | empty |
| 2 | 205 | 0.65 | 0.84 | 22 | empty |
| 3 | 67 | 0.37 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1130 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1099 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 1096 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 1IQA · Crystal structure of the extracellular domain of mouse rank ligand · the same entry in another collection · chain A against A, TM-score 1.00
- O35235 · AlphaFold monomer V2.0 prediction for tumor necrosis factor ligand superfamily member 11… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35235
- Elsewhere: RCSB PDB 1IQA · PDBe 1IQA · UniProt O35235
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