MolNFT v1 · #103870 · protein

Crystal structure of a glutathione transferase from gordonia bronchialis dsm 43247, target efi-507405

4PTS · Glutathione S-transferase: “Crystal structure of a glutathione transferase from gordonia bronchialis dsm 43247, target efi-507405”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #103870 on GenesisL1: 3D structure…

PDB: 4PTS
Type: protein
Length: 654 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase
EC: 2.5.1.18
UniProt: D0L9F3
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase (EC 2.5.1.18)	protein	321	45% helix, 7% strand	D0L9F3
B	Glutathione S-transferase (EC 2.5.1.18)	protein	333	42% helix, 7% strand	D0L9F3

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.74	0.96	26	empty
2	349	0.64	0.79	27	empty
3	178	0.44	0.74	22	empty
4	112	0.39	0.75	21	empty
5	82	0.33	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 1224 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

4PTS · Crystal structure of a glutathione transferase from Gordonia bronchialis DSM 43247… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D0L9F3
Elsewhere: RCSB PDB 4PTS · PDBe 4PTS · UniProt D0L9F3

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