MolNFT v1 · #103852 · protein
Crystal structure analysis of N terminal region containing the dimerization domain and DNA binding domain of hu PROTEIN(HISTONE like protein-DNA binding) from mycobacterium tuberculosis [H37RV]
4PT4 · DNA-binding protein hu homolog: “Crystal structure analysis of N terminal region containing the dimerization domain and DNA binding domain of…”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #103852 on GenesisL1…
- PDB
- 4PT4
- Type
- protein
- Length
- 196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein hu homolog
- UniProt
- P95109
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein hu homolog | protein | 99 | 40% helix, 28% strand | P95109 |
| B | DNA-binding protein hu homolog | protein | 97 | 41% helix, 28% strand | P95109 |
Ligands and binding sites
- FMT · Formic acid · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.39 | 0.76 | 16 | empty |
| 2 | 69 | 0.34 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2099 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4PT4 · Crystal structure Analysis of N terminal region containing the dimerization domain and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P95109
- Elsewhere: RCSB PDB 4PT4 · PDBe 4PT4 · UniProt P95109
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