MolNFT v1 · #103737 · protein

Crystal structure of BCL-xl hexamer

4PPI · BCL-2-like protein 1: “Crystal structure of BCL-xl hexamer”. X-ray diffraction, 3 pockets (best druggability 0.50). MolNFT v1 #103737 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4PPI
Type: protein
Length: 135 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-2-like protein 1
UniProt: Q07817
Pockets: 3 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BCL-2-like protein 1	protein	135	71% helix, 0% strand	Q07817

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.50	0.79	25	empty
2	86	0.47	0.81	13	empty
3	73	0.36	0.76	13	empty

Compared structures

4PPI · Crystal structure of Bcl-xL hexamer · the same entry in another collection · chain A against A, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 4PPI · PDBe 4PPI · UniProt Q07817

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